Linking drug-eluting stent kinetics and clinical outcomes: insights from optical coherence tomography.

Drug-eluting stent release kinetics matter. This is demonstrated by the study of Guagliumi et al. (1) in this issue of JACC: Cardiovascular Interventions, which provides a description of the vascular responses to the next generation Resolute zotarolimus-eluting (sustained release) stent (Medtronic, Minneapolis, Minnesota). Vascular responses to this Resolute stent are compared with those of the original Endeavor stent (Medtronic), which delivers a more rapid release of zotarolimus.